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新的研究成果: 姜黄显示出中和癌症的好处  

2014-11-13 00:00:26|  分类: 抗癌防癌 |  标签: |举报 |字号 订阅

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 A common spice frequently used in Asian cooking may hold the key to hindering the advancement of mesothelioma, a type of cancer found in the lining of the lung.

一种在亚洲烹饪中经常使用的香料,可能是阻碍间皮瘤(在肺内层发现的一种癌症)生长的关键

Scientists from Case Western Reserve University, Cleveland, Ohio, and the Georg-Speyer-Haus, Frankfurt, Germany, have shown that applying curcumin – derived from the spice turmeric – in the presence of cancer-inhibiting peptides can boost the strength of a cancer-slowing protein inhibitor. It is hoped the study’s findings can lead scientists a step closer to understanding how patients can become cancer free. 

来自俄亥俄州克利夫兰凯斯西储大学的科学家和德国法兰克福的Georg-Speyer-Haus,已经证明应用源自于香料姜黄的姜黄素 - 癌症抑制肽的存在可以提高癌症放慢蛋白酶抑制剂的力量。希望研究结果能让科学家更进一步了解癌症病人如果成为无癌的。


Understanding the value of curcumin for cancer patients 

了解姜黄素对癌症患者的价值

Curcumin is an antioxidant and an active ingredient in turmeric. Antioxidants are compounds frequently found in plants and known to protect the body’s cells from the onslaught of activated molecules – known as free radicals – that are believed to cause a variety of diseases and disorders.

姜黄素是一种抗氧化剂和姜黄中的一种活性成分。抗氧化剂是在植物中时常发现的化合物和已知的保护身体的细胞免受活化分子(称之为自由基)的冲击 — 自由基被认为是导致各种各样的疾病和障碍的原因。

According to the American Cancer Society, benefits of turmeric can be illustrated by the fact that curcumin has demonstrated some anti-cancer effects in the lab by interfering with several significant molecular pathways believed to be involved in cancer presence, growth, and spread. Research results have shown curcumin inhibited the formation of cancer-causing enzymes in rodents, according to the American Cancer Society, which added that curcumin can kill and slow the growth of cancer cells in vitro. 

据美国癌症协会提到的,姜黄的好处,已经可以通过姜黄素在实验室一些抗癌效果的事实所证明,它的作用是通过干扰被认为是参与癌症的增长和扩散的几个重要分子途径而存在的。研究结果表明姜黄素抑制啮齿动物的致癌的形成酶,据美国癌症协会介绍,姜黄素能杀死和减缓试管中癌细胞的增长。

It has also been shown to reduce cancer growth and shrink tumors of lab animals. 

它也已被证明能够降低实验室动物的癌症增长和缩小肿瘤。


Why is curcumin so effective at preventing cancer cell growth? 

为什么姜黄素防止癌细胞的生长如此有效?

A 2011 study looked at the benefits of turmeric by taking advantage of the fact that curcumin stays in the intestine rather than absorbing into the bloodstream, leading researchers to investigate whether it might reduce the number of cancer precursors in the rectum and colon. 

2011年的一项研究观察姜黄通过将姜黄素保留在肠道而不是吸收到血液中这一事实的的好处,主要研究人员调查它是否会减少在直肠和结肠中癌症的数量。

They found that smokers who consumed 4 grams of curcumin a day had fewer abnormal crypt foci following the study than smokers who took only 2 grams a day, who showed no change. Research continues on whether curcumin can actually reduce the prevalence of colon and rectum cancers – leaving patients cancer free. 

他们发现,吸烟者每天消耗4克的姜黄素具有较少的异常小囊病灶,接着研究比起吸烟者一天仅服用2克则没有变化。继续的研究是姜黄素是否可以减少结肠和直肠癌症的患病率 - 让患者无癌。


Science is looking at ways to slow down the progression of cancer 

科学正在研究如何减缓癌症的进展

In the most recent study, Onio and German investigators analyzed tissue samples of mesothelioma tumors from patients at three geographical locations across the United States, comparing patient mortality and the specific type of mesothelioma suffered.

在最近的研究中,Onio和德国研究人员分析了来自美国三个地理位置的间皮瘤肿瘤病人的组织样本,比较患者死亡率和特定类型的间皮瘤。 

While mesothelioma has been linked to asbestos exposure, many of the 43,000 people killed worldwide by this cancer on an annual basis have never been exposed to asbestos. While widespread, treatment options have remained limited, with less-than-optimal results. 

虽然间皮瘤与石棉接触有关,这种癌症每年全世界多达43000人死亡从未暴露于石棉。同时普遍的治疗方案一直有限,结果不太理想。

Senior research author Afshin Dowlati, MD, Professor of Medicine – Hematology/Oncology, Case Western Reserve University School of Medicine, was quoted in a statement by the University confirming that better ways to treat mesothelioma are necessary. 

凯斯西储大学医学院的高级研究作者Afshin Dowlati博士,血液学/肿瘤学医学教授,在引述了通过大学一份声明中确认更好的方法治疗间皮瘤是必要的。

“We now understand the mechanisms that drive cell proliferation and growth in malignant mesothelioma,” said Dowlati, a member of the Case Comprehensive Cancer Center, referring to the study’s findings. 

“我们现在理解了推动细胞增殖和恶性间皮瘤的增长的机制,“Dowlati说,他是综合癌症中心的一员,指的是研究结果。

It is believed that many cancers, mesothelioma included, are triggered by the action of an intraceullular protein and transcription factor known as STAT3. STAT stands for “signal transducer and activator of transcription.” A signal transducer and activator acts as a pathway for instructing growth and survival of cells throughout the body. The term “transcription factor” refers to a protein that controls genetic information that tells cells how to perform. 

相信包括间皮瘤的许多癌症,是由intraceullular蛋白和称之为STAT3的转录因子触发的STAT代表“信号传感器和转录的激活。“ 一个信号传感器和催化剂作为整个身体指示细胞生长和生存的通路 。“转录因子”这一术语指的是告诉细胞如何执行控制遗传信息一种蛋白质

Cancer is linked to the presence of STAT3 because the transcription factor has a reputation for providing misdirection that sparks the onset of human cancers and then fuels their continued growth. However, the protein inhibitor known as PIAS3, which stands for “protein inhibitor of activated STAT3,” has the ability to slow, and even block, the ability of STAT3 to spur cancer growth. 

癌症与STAT3的存在相关的,因为转录因子具有一个提供点燃误导人类癌症发作的信誉,然后供给燃料持续增长。然而,称之为PIAS3的蛋白质抑制剂,即“激活的STAT3蛋白抑制剂”,有能力放慢甚至阻止STAT3刺激肿瘤生长的能力。


Has science discovered the true ‘anticancer’ power of curcumin? 

科学发现了姜黄素真正的抗癌的能力吗?

Investigators were able to link levels of PIAS3 with STAT3 activity in each tissue sample. In addition, the researchers assessed the impact of curcumin and peptides extracted from PIAS3 on malignant mesothelioma cells in vitro. 

调查人员能够联系每个组织样本中PIAS3与STAT3活动的水平。此外,研究人员评估了从PIAS3中提取的姜黄素和肽对体外恶性间皮瘤细胞的影响。

Curcumin and PIAS3 peptides raised PIAS3 levels in the study, which inhibited the cancer-causing activity of STAT3, even killing off mesothelioma cells. These latest findings are believed to provide proof that these two compounds are effective in treating malignant mesothelioma. The research is characterized as representing the first steps toward an actual clinical trial for treatment. 

在这项研究中提升PIAS3水平的姜黄素和PIAS3肽,它抑制致癌活性的STAT3,甚至杀死间皮瘤细胞。这些最新发现被认为是为这两个化合物有效治疗恶性间皮瘤提供相关证明。该研究被描述为代表接近实际临床试验治疗的第一步


A potential treatment strategy for cancer patients is on the horizon 

对癌症患者的一个潜在的治疗策略即将来临

The medical community has long observed that mesothelioma does not progress consistently in patients even when stages, grades and clinical presentation of the tumor are very comparable. This suggests that the presence of PIAS3 in patients could serve as a marker because its expression was found to have a positive impact on patient survival, based on the study’s findings. 

医学界一直观察到间皮瘤患者并不会一直增长,即使在各阶段、分级和肿瘤的临床表现是有可比性的。这就提示存在PIAS3的患者可以作为一个标志,因为基于该研究所发现它的表达被发现对患者生存产生积极影响。 

The results have led investigators to suggest that PIAS3 activation could be a therapeutic strategy for mesothelioma patients. 

这结论使研究者提议PIAS3激活可用于间皮瘤患者的一个治疗策略。

“Mesothelioma patients who have low PIAS3 and high STAT3 have a greater chance of dying early,” explained Dowlati. “On the flip side, those patients with high PIAS3 levels have a 44 percent decreased chance of dying in one year, which is substantial.”

 “那些有低PIAS3和高STAT3的间皮瘤患者有更大的机会早死,“Dowlati解释道。“另一方面,那些有高PIAS3水平的患者,有44%在一年内的死亡率下降,这是实质性的。”

The scientists believe these findings may lead to further investigation of what role PIAS3 could hold in inhibiting other cancers that are caused by STAT3 action. 

科学家们认为,这些发现可能会导致进一步调查PIAS3可以保存在抑制由STAT3活动造成的其他癌症中扮演什么角色

References:

参考文献:

http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/herbsvitaminsandminerals/turmeric

http://casemed.case.edu/newscenter/news-release/newsrelease.cfm?news_id=229 

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