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【转载】为肝脏提供最好保护的山姆医(SAMe)  

2014-06-21 18:36:21|  分类: 健康保健 |  标签: |举报 |字号 订阅

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山姆医SAMe)在保护和增强肝功能方面有非凡的能力,这一点在很多研究中已经得到证据确凿的证实。一个戏剧性的例子是,那些摄取SAMe消费的酗酒者中已被证明血液中酒精含量是明显低于控制量。 2010年,研究人员能够确定原因:SAMe通过增加特别是参与酒精代谢的肝细胞内的基因突变提高了肝脏的酒精消除速率。 SAMe水平的不足同样也与各种肝脏疾病,包括非酒精性脂肪肝和非酒精性脂肪肝炎有关,都变成越来越常见疾病,其特点是脂肪堆积在肝脏组织,可能发展为肝硬化和全面的肝衰竭。科学家认为SAMe补充剂可以防止这些疾病的发作以及这些有可能致命的状态的发展。


SAMe’s extraordinary capacity to protect and enhance liver function has been well-documented in a wealth of studies. To take one dramatic example, blood alcohol levels among binge drinkers who ingest SAMe at the point of consumption have been shown to be significantly lower than controls.1 In 2010, researchers were able to determine why: SAMe boosts the liver’s alcohol elimination rate by increasing expression of genes within liver cells that are specifically involved in alcohol metabolism.1 Insufficient levels of SAMe have also been linked to a variety of liver diseases, including nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, both increasingly common disorders characterized by fat deposits in liver tissue that may progress to cirrhosis and full-blown liver failure.2,3 Scientists believe SAMe supplementation can prevent the onset and progression of these potentially fatal conditions.


References (参考文献)

1. Bardag-Gorce F, Oliva J, Wong W, et al. S-adenosylmethionine decreases the peak blood alcohol levels 3h after an acute bolus of ethanol by inducing alcohol metabolizing enzymes in the liver. Exp Mol Pathol. 2010 Sep 7.

2. Wortham M, He L, Gyamfi M, Copple BL, Wan YJ. The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Dig Dis Sci. 2008 Oct;53(10):2761-74.

 

3. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem. 2010 Jun 11;285(24):18528-36.

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