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关于IP-6 +肌醇互补的癌症治疗的讨论  

2016-04-24 13:35:05|  分类: 抗癌防癌 |  标签: |举报 |字号 订阅

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IP-6 + Inositol complementary cancer therapy


 on: March 28, 2010, 07:09:21 AM ?
I would like to make an inquiry about the use of IP6 plus Inositol for people with cancer in general, and also specifically during chemo with Cisplatinum and VP-16. My sister is the patient. She's a 52 yo newly diagnosed with two primaries: NSCLC stage 4 w/single cerebellar lesion (lung biopsy large cell neuroendocrine carcinoma) and squamous cell laryngeal cancer. PET scan showed lymph node involvement in thoracic and clavicular region. Another sister in our family has been researching complementary therapies for cancer and came across numerous scientific articles describing the use of the IP6 + Inositol supplement with very good results and no problematic side effects. Does anyone here have experience using it?
Below is the abstract for one of the most recent articles (Feb 2010) on the use of IP6 + Inositol in cancer treatment. One of its authors is Dr. Shamsuddin, a MD PhD at University of Maryland who is one of the world's premiere researchers on the use of IP6 plus Inositol for cancer treatment as well as cancer prevention.  The abstract describes the mechanisms of action. Other articles describe studies in animals and in humans that are showing both reduction in tumor size and reduction of chemo side effects in cancer patients who have supplemented their chemo with IP6 + Inositol.
We are very interested--and would be immensely grateful--to hear from other patients or families who have used this complementary therapy and what your experience was, and also to hear from Dr. West and your Naturopathic colleague about your thoughts on IP6 + Inositol.  The family has purchased the supplement our sister is taking it now as a complementary therapy to her chemo and upcoming radiation.  Thank you in advance for responding to this inquiry and for the valuable resource that CancerGrace provides to patients and families.
IP6 in Cancer Therapy: Past, Present and Future
Authors: Matejuk, Agata; Shamsuddin, Abulkalam
Source: Current Cancer Therapy Reviews, Volume 6, Number 1, February 2010 , pp. 1-12(12)
Publisher: Bentham Science Publishers


Abstract:
Inositol hexaphosphate (IP6) and its derivatives are naturally occurring, most abundant polyphosphorylated carbohydrates in organisms as diverse as yeast, endo-parasites, mammals and plants. IP6 represents a major metabolic pool in cellular phosphate pathways involved in vital functions such as signal transduction, regulation of cell proliferation and differentiation, RNA export, DNA repair, energy transduction and ATP regeneration. IP6 has been recognized as a natural antioxidant and agent preventing calcification and kidney stone formation, normalizing cholesterol concentrations, and reducing pathological platelet activity. The most striking effect of IP6 has been documented in cancer prevention by controlling tumor growth, progression and metastasis. Its anti-cancer actions involve boosting immunity, antioxidant properties, reducing cell proliferation and inducing differentiation of malignant cells. This is brought about via lowerphosphate inositol phosphates (IP1-5) and probably by the highly phosphorylated derivatives (PP-IP4 and PP-IP5); however the selectivity of its metabolite(s) in anti-cancer activity has not been adequately investigated. Preliminary in vitro studies show that IP6 synergistically acts with conventional anti-cancer drugs like tamoxifen overcoming its resistance thus enhancing the anticancer effect of conventional chemotherapy. In this review we present anti-cancer abilities of IP6 and its metabolites and discuss their future use as potential drug(s) for cancer prevention and therapy.


Keywords: IP6; inositol; phytate; cancer chemotherapy; nutritional supplement; nutraceuticals

 

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